KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC , Saligrama N*, Davis MM* *corresponding author

Science. DOI: 10.1126/science.abi9591

2022

Evolution of Cytomegalovirus-Responsive T Cell Clonality following Solid Organ Transplantation

Higdon LE, Schaffert S, Huang H, Montez-Rath ME, Lucia M, Jha A, Saligrama N, Margulies KB, Martinez OM, Davis MM, Khatri P, Maltzman JS.

J Immunol.207(8):2077-2085.

2021

Functional Consequences of Memory Inflation after Solid Organ Transplantation

Higdon LE, Schaffert S, Cohen RH, Montez-Rath ME, Lucia M, Saligrama N, Margulies K, Martinez OM, Tan JC, Davis MM, Khatri P, Maltzman JS.

J Immunol.207(8):2086-2095

Clonally expanded CD8 T cells patrol Alzheimer’s cerebrospinal fluid

Gate D, Saligrama N, Leventhal O, Yang AC, Unger MC, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, Galasko DR, Davis MM, Coray TW.

Nature. 577 (7790):399-404

2020

Opposing T cell responses in Experimental Autoimmune Encephalomyelitis

Saligrama N, Zhao F*, Sikora MJ*, Serratelli WS, Fernandes RA, Louis MD, Winnie Y, Xuhuai Ji, Idoyaga J, Mahajan VB, Steinmetz LM, Chien YH, Hauser SL, Oksenberg JR, Garcia KC, and Davis MM.*contributed equally

Nature. 572, 481-487

2019

Single cell analysis of neurogenic niches during aging reveals age-dependent cell composition changes and interaction between T cells and neural stem cells

Dulken BW*, Buckley MT*, Negredo PN*, Saligrama N, Cayrol R, Leeman DS, George B, Boutet SC, Hebestreit K, Pluvinage JV, Wyss-Coray T, Weissman IL, Vogel H, Davis MM, and BrunetA. *contributed equally

Nature. 571, 205-210

2019

Transcript-indexed ATAC-seq for precision immune profiling

Satpathy AT*, Saligrama N*, Buenrostro JD*, Wei Y, Wu B, Rubin AJ, Granja JM, Li R, Lareau CA, Li R, Qi Y, Parker KR, Mumbach MR, Serratelli WS, Gennert DG, Schep AN, Corces MR, Khodadoust MS, Kim YH, Khavari PA, Greenleaf WJ, Davis MM, and Chang HY. **Co-first authors, *contributed equally

Nature Medicine. 24, 580-590

2018

A macrophage colony-stimulating factor producing γδ T cell subset prevents malarial parasitemic recurrence

Mamedov MR, Scholzen A, Nair RV, Cumnock K, Kenkel JA, Oliveira JHM, Trujillo DL, Saligrama N, Zhang Y, Rubelt F, Schneider DS, Chien YH, Sauerwein RW, and Davis MM.

Immunity. 48 (2): 350-363

2018

Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis

Saligrama N, Case LK, Krementsov DN, and Teuscher C.

Federation of American Societies for Experimental Biology. 28 (4): 1898-1909

2016

Identification of genetic determinants of the sexual dimorphism in CNS autoimmunity

*Bearoff F, *Case LK, Krementsov DN, Wall EH, Saligrama N, Blankenhorn EP, and Teuscher C. *contributed equally.

PLoS ONE. 10 (2)

2015

Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

Case LK, Wall EH, Osmanski EE, Dragon JA, Saligrama N, Zachary JF, Lemos B, Blankenhorn EP, and Teuscher C.

Genome Biology. 16 (1): 28

2015

Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis

Saligrama N, del Rio R, Case LK, Noubade R, and Teuscher C.

Journal of Immunology. 191(2): 614-22

2013

The Y Chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease

Case LK, Wall EH, Dragon JA, Saligrama N, Krementsov DN, Moussawi M, Zachary JF, Huber SA, Bunn JY, Blankenhorn EP, and Teuscher C.

Genome Research. 23 (9): 1474-85

2013

H1R expression by CD11b+ cell is not required for susceptibility to experimental allergic encephalomyelitis

Saligrama N, Noubade R, Case LK, Poynter EM, and Teuscher C.

Cellular Immunology. 278: 27-34

2012

Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system

Saligrama N, Noubade, R, Case LK, del Rio R, and Teuscher C.

European Journal of Immunology.42: 1536–1546

2012

Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system

del Rio R, Noubade R, Saligrama N, Wall EH, Krementsov DN, Poynter ME, Zachary JF, Thurmond RL, Teuscher C.

Journal of Immunology.188(2): 541-7

2012

Chromosome Y regulates survival following coxsackievirus B3 infection

Case LK, Toussaint L, Moussawi M, Roberts B, Saligrama N, Brossay L, Huber SA, and Teuscher C.

Genes Genomes Genetics. 2(1): 115-21

2012

Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis

Blankenhorn EP, Butterfield R, Case LK, Wall EH, del Rio R, Diehl SA, Krementsov DN, Saligrama N, and Teuscher C.

Annals of Neurology. 70(6): 887-96

2011

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

Noubade R, Krementsov DN, Del Rio R, Thornton T, Nagaleekar V, Saligrama N, Spitzack A, Spach K, Sabio G, Davis RJ, Rincon M, Teuscher C.

Blood. 118(12): 3290-300

2011

Mapping the complement C1q binding site in Haemonchus contortus calreticulin

Saligrama N*, Suryawanshi A*, Agarwal M, Singh BP, Joshi P. *contributed equally

Molecular and Biochemical Parasitology. 166(1): 42-6

2009

Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression

Noubade R, Saligrama N, Spach K, Del Rio R, Blankenhorn EP, Kantidakis T, Milligan G, Rincon M, Teuscher C.

Journal of Immunology.180(11): 7471-9

2008

SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-susceptibility locus Aod2/Idd3/Eae3

del Rio R, Noubade R, Subramanian M, Saligrama N, Diehl S, Rincon M, Teuscher C.

Genes and Immunity. 9(2): 115-21

2008